The 28-year-old has struggled to break his way into United's first team since Jose Mourinho took control of the club in 2016, making only four league appearances this season.
His last appearance for the club came against Yeovil Town in the fourth round of the FA Cup but the defender has not appeared on a 'Red Devils' teamsheet for a top flight fixture since January 1.
However his woes look set to be ending as reports from publication 'Goal' claim Serie A giants are keen to bring Darmian to Turin to replace Stephen Lichtsteiner, who, at 34, is set to leave the club at the end of his current contract in the summer.
He shouldn't be an expensive purchase for Juventus as he joined the Premier League club for £13million in 2015 from their rivals Torino and has failed to post performances that would warrant an increase in valuation.
Darmian hasn't been included for United's trip to Sevilla for their Champions League first leg on Wednesday night.