The diminutive Argentine goes into the game just one goal short of a century of European goals, whilst he is also finely poised on 49 strikes this calendar year.
As such, the 30-year-old would bring up the two milestones with a goal this evening taking himself to 50 and 100 not-out.
The Barca star has found the net an incredible 96 times in the Champions League, with three more in the European Super Cup, leaving him within touching distance of three figures.
Furthermore, a sensational 10 months, including a red-hot start to the new season, has seen Messi reach 49 goals for the year by the midway point in October, with it very much a case of when rather than if he breaks the 50 mark.
With this in mind, Messi, alongside his will to win and desire to be the best, has yet another reason to be motivated for tonight's game.
Will he manage to bring up his milestones this evening? Join us later for live coverage of the game to find out!